Fatigue-related impairment in the speed, accuracy and variability of psychomotor performance: comparison with blood alcohol levels

17 hours of sustained wakefulness, such as a long day in the office, has been shown to result in behavioural changes equivalent to drinking 2 glasses of wine.

After 24 hours, you may act as if you have drunk 4 glasses of wine. Diminished cognitive performance can have huge repercussions for professionals whose jobs demand critical attention to detail, such as surgeons, pilots, and drivers.